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Journal of the Korean Chemical Society (JKCS)

ISSN 1017-2548(Print)
ISSN 2234-8530(Online)
Volume 55, Number 5
JKCSEZ 55(5)
October 20, 2011 

 
Title
Resolution of Aryl α-Aminoalkyl Ketones on a Doubly Tethered Liquid Chromatographic Chiral Stationary Phase Based on (+)-(18-Crown-6)-2,3,11,12-tetracarboxylic Acid
Author
Kab Bong Jin, Hee Jin Kim, Myung Ho Hyun*
Keywords
Aryl α-aminoalkyl ketone, Chiral stationary phase, (+)-(18-Crown-6)-2,3,11,12-tetracarboxylic acid, Liquid chromatography, Resolution
Abstract
A doubly tethered chiral stationary phase (CSP) based on (+)-(18-crown-6)-2,3,11,12-tetracarboxylic acid was applied to the resolution of various aryl α-aminoalkyl ketones with the use of 80% ethanol in water containing 10 mM sulfuric acid as a mobile phase. The chiral resolution was quite successful, the separation factors (α) and the resolutions (RS) being in the range of 1.39-2.05 and 3.18-5.22, respectively. The separation factors (α) on the doubly tethered CSP were slightly worse than those on the corresponding singly tethered CSP. However, the resolutions (RS) on the doubly tethered CSP were generally greater than those on the corresponding singly tethered CSP. The chromatographic behaviors for the resolution of aryl α-aminoalkyl ketones on the doubly tethered CSP were demonstrated to be dependent on the type and the content of the organic and acidic modifiers in aqueous mobile phase and the column temperature.
Page
751 - 755
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