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Journal of the Korean Chemical Society (JKCS)

ISSN 1017-2548(Print)
ISSN 2234-8530(Online)
Volume 55, Number 3
JKCSEZ 55(3)
June 20, 2011 

Microwave-induced one-pot Synthesis of Coumarins Using Potassium Dihydrogen Phosphate as a Catalyst Under Solvent-free Condition

무 용매 조건에서 potassium dihydrogen phosphate를 촉매로 사용하는 쿠마린의 마이크로파-유도 단일 용기 내 합성
Kirti S Niralwad, Bapurao B Shingate, Murlidhar S Shingare*

Kirti S Niralwad, Bapurao B Shingate, Murlidhar S Shingare*
Pechmann 축합, 쿠마린, Potassium dihydrogen phosphate,무 용매, 마이크로파 , Pechmann condensation, Coumarins, Potassium dihydrogen phosphate, Solvent-free, Microwave
Potassium dihydrogen phosphate는 마이크로파 조사조건에서 용매 없이 페놀과 아세토아세트산 에틸의 Pechmann 축합반응에 의하여 쿠마린을 합성하는 효과적인 촉매로 밝혀졌다. 이 방법은 쿠마린 합성에 있어서 소량의 촉매를 필요 로 하며 수율이 높고, 반응이 깨끗할 뿐만 아니라 반응 시간이 짧은 장점들을 가지고 있다.

Potassium dihydrogen phosphate was found to be an efficient catalyst for the Pechmann condensation of phenols with ethyl acetoacetate, leading to the formation of coumarins under microwave-irradiation and solvent-free condition. This procedure offers several advantages, including the low loading of catalysts, high yields, clean reactions, short reaction time for the synthesis of coumarins.

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