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Journal of the Korean Chemical Society (JKCS)

ISSN 1017-2548(Print)
ISSN 2234-8530(Online)
Volume 55, Number 3
JKCSEZ 55(3)
June 20, 2011 

Synthesis, Spectroscopic, and Biological Studies of Chromium(III), Manganese(II),
Iron(III), Cobalt(II), Nickel(II), Copper(II), Ruthenium(III), and Zirconyl(II)
Complexes of N1,N2-Bis(3-((3-hydroxynaphthalen-2-yl)methylene-amino)propyl)

크롬(III), 망간(II), 철(III), 코발트(II), 니켈(II), 구리(II), 루테늄(III) 및 산화 지르
코늄(II) 착물에 대한 합성과 분광학 및 생물학적 연구
Ahmed N Al Hakimi, Mohamad M E Shakdofa, Ahemd M A El Seidy, Abdou S El Tabl*

Ahmed N Al Hakimi, Mohamad M E Shakdofa, Ahemd M A El Seidy, Abdou S El Tabl*
착물, 합성, Schiff 염기, 자성, 생물학적 연구 , Complexes, Synthesis, Schiff base, Magnetism, Biological studies
N1,N2-bis(3-((3-hydroxynaphthalen-2-yl)methylene-amino)propyl)phthalamide (H4L, 1) 의 새로운 크롬(III), 망간(II), 철(III), 코발트(II), 니켈(II), 구리(II), 루테늄(III) 및 산화 지르코늄(II) 착물을 합성하여 원소분석, 물리적 성질 및 분광학적 으로 특성을 규명하였다. 분광학적 결과를 통해 이 리간드는 [H4LMX2(H2O)]·nH2O (M = Cu(II), Ni(II), Co(II), X = Cl 또 는 NO3)의 일반식을 갖는 착물2-5에서는 중성의 삼배위 리간드로 행동한다. 또는 [H4L(ZrO)2Cl2]·8H2O 의 일반식을 갖는 착물 6-9 에서는 이염기성 육배위 리간드로 행동한다. DMF 용액에서의 몰전기전도도 실험결과 이들 착물은 비이온성을 나타낸다. 고체 구리착물 2, 5 및 6 의 ESR 스펙트럼에서 g||>g>ge 을 보이는데, 이는 일그러진 팔면체구조와 큰 공유결합 성을 갖는 dx 2 -y 2 오비탈에 비공유 전자쌍이 존재함을 의미한다. 이합체 구리(II) 착물 [H2LCu2Cl2(H2O)4]·3H2O (6)에 대해 두 구리원자 사이의 거리를 ESR 스펙트럼으로부터 추정한 parallel component 의 field zero splitting 파라메타를 이용하여 계 산하였다. 이들 화합물의 항박테리아 및 항균 활성도를 측정한 결과, 몇가지 금속 착물의 경우 표준시약인 tetracycline (박 테리아) 및 Amphotricene B (균류)보다 더 큰 저해효과를 보였다.

Novel chromium(III), manganese(II), iron(III), cobalt(II), nickel(II), copper(II), ruthenium(III), and zirconyl(II) complexes of N1,N2-bis(3-((3-hydroxynaphthalen-2-yl)methylene-amino)propyl)phthalamide (H4L, 1) have been synthesized and characterized by elemental, physical, and spectral analyses. The spectral data showed that the ligand behaves as either neutral tridentate ligand as in complexes 2-5 with the general formula [H4LMX2(H2O)]·nH2O (M=Cu(II), Ni(II), Co(II), X = Cl or NO3), neutral hexadentate ligand as in complexes 10-12 with the general formula [H4LM2Cl6]·nH2O (M=Fe(III), Cr(III) or Ru(III)), or dibasic hexadentate ligand as in complexes 6-9 with the general formula [H2LM2Cl2(H2O)4]·nH2O (M = Cu(II), Ni(II), Co(II) or Mn(II), and 13 with general formula [H4L(ZrO)2Cl2]·8H2O. Molar conductance in DMF solution indicated the non-ionic nature of the complexes. The ESR spectra of solid copper(II) complexes 2, 5, and 6 showed g||>g>ge, indicating distorted octahedral structure and the presence of the unpaired electron in the dx 2 -y 2 orbital with significant covalent bond character. For the dimeric copper(II) complex [H2LCu2Cl2(H2O)4]·3H2O (6), the distance between the two copper centers was calculated using field zero splitting parameter for the parallel component that was estimated from the ESR spectrum. The antibacterial and antifungal activities of the compounds showed that, some of metal complexes exhibited a greater inhibitory effect than standard drug as tetracycline (bacteria) and Amphotricene B (fungi).

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