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ISSN 1017-2548(Print) ISSN 2234-8530(Online)
Volume 55, Number 2
JKCSEZ 55(2)
April 20, 2011 |
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Title |
Novel Synthesis of bis Acetylated Hybrid Pyrazoles as Potent Anticandidiasis Agents
항칸다디아 활성이 우수한 bis acetylated hybrid pyrazoles의 합성 연구
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Author |
V Kanagarajan, M R Ezhilarasi, M Gopalakrishnan*
V Kanagarajan, M R Ezhilarasi, M Gopalakrishnan* |
Keywords |
피라졸, 아실화 반응, 스펙트럼분석, 칸다디아 균, 항칸다디아 활성
, Bis acetylated hybrid pyrazoles, In situ acetylation, Spectral analysis, Candida sp., Anticandidal activity
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Abstract |
Bis acetylated hybrid pyrazoles 을 합성하여 이들 화합물에 대해 녹는점, 원소분석, MS, FT-IR, one-dimensional 1H,- 및 13C-NMR로 분석하였다. 합성한 화합물들에 대해 in vitro 항균활성을 Candida sp. namely Candida albicans, Candida glabrata, Candida parapsilosis, Candida dubliniensis 및 Candida tropicali 균에 대해 수행하였다. Pyrazoles의 페 닐고리에 작용기(-CH3, -OCH3, -F, -Cl, 및 Br)가 있는 화합물은 Candida species에 대해서 강한 활성을 나타내었다.
A new series of bis acetylated hybrid pyrazoles were synthesized and characterized by their melting point, elemental analysis, MS, FT-IR, one-dimensional 1H, and 13C NMR spectroscopic data. All the synthesized compounds were tested for their in vitro antifungal activities against Candida sp. namely Candida albicans, Candida glabrata, Candida parapsilosis, Candida dubliniensis and Candida tropicalis. A close inspection of the in vitro anticandidal activity profile in differently electron donating (CH3 and OCH3) and electron withdrawing (-F, -Cl, and Br) functional group substituted phenyl rings of novel hybrid pyrazoles exerted strong anticandidal activity against all the tested Candida species.
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256 - 261 |
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