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Journal of the Korean Chemical Society (JKCS)

ISSN 1017-2548(Print)
ISSN 2234-8530(Online)
Volume 55, Number 2
JKCSEZ 55(2)
April 20, 2011 

 
Title
Highly Convenient and Large Scale Synthesis of 5-chloroindole and its 3-substituted Analogues

5-Chloroindole계 화합물의 Large Scale 합성
Author
Laxminarayana Keetha, Sadanandam Palle, Vinodkumar Ramanatham*, Mukkanti Khagga, Rajendiran Chinnapillai

Laxminarayana Keetha, Sadanandam Palle, Vinodkumar Ramanatham*, Mukkanti Khagga, Rajendiran Chinnapillai
Keywords
5-haloindoles, 염화 구리 (I) , N-methyl-2-pyrrolidone, halogen-halogen 교환반응 , 5-haloindoles, copper (I) chloride, N-methyl-2-pyrrolidone, halogen-halogen exchange.
Abstract
CuCl과 N-methyl-2-pyrrolidone을 이용하여 5-bromoindole을 halogen - halogen 교환반응을 통하여 5-chloroindole계 화합물을 합성하는 one-pot대량합성방법을 개발하였다.

A large scale and commercially feasible synthesis of 5-chloroindole and its 3-substituted analogues has been described via a halogen - halogen exchange reaction from 5-bromoindole and its derivatives using cuprous chloride and dipolar aprotic solvent N-methyl-2-pyrrolidone in one pot with good yields.

Page
240 - 242
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