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Journal of the Korean Chemical Society (JKCS)

ISSN 1017-2548(Print)
ISSN 2234-8530(Online)
Volume 55, Number 2
JKCSEZ 55(2)
April 20, 2011 

Synthesis, Antibacterial and Antifungal Activities of Some Cobalt(II) and Nickel(II) Complexes of Thiosemicarbazones

Thiosemicarbazones의 몇 가지 코팔트(II) 및 니켈(II) 착물에 대한 합성, 항박테리 아 및 항균 활성
Surendra Prasad*, Ram K Agarwal,

Surendra Prasad*, Ram K Agarwal,
코발트(II), 니켈(II), Thiosemicarbazones, 코발트(II) thiosemicarbazone 착물, 니켈(II) thiosemicarbazone착물, 생물학적 성질 , Cobalt(II), Nickel(II), Thiosemicarbazones, Cobalt(II) thiosemicarbazones complexes, Nickel(II) thiosemicarbazones complexes, Biological properties
두 가지 새로운 thiosemicarbazone으로, 예를 들면, 4[N-(4'-ethylbenzalidene)amino]antipyrine thiosemicarbazone(EBAAPTS) 및 4[N-(2',4'-dimethylbenzalidene)amino]antipyrine thiosemicarbazone(DMBAAPTS)를 합성하여 그 특성을 규명하였다. 이들 thiosemicarbazone(EBAAPTS 및 DMBAAPTS)의 코발트(II) 및 니켈(II)에 대한 착물화 특성을 조사하였다. EBAAPTS 및 DMBAAPTS와 코발트(II) 및 니켈(II) 염과의 반응을 뜨거운 에탄올 용액에서 수행한 결과, 일반적 조성으로 [MX2(L)H2O] (M=Co2+ 또는 Ni2+; X=Cl, Br, NO3 , NCS또는 CH3COO; L=EBAAPTS 또는 DMBAAPTS)을 갖는 새로운 착물의 형성을 확인하였다. 새롭게 합성한 이들 착물에 대해 원소분석, 분자량, 몰전도도, 자기수자율, 적외선 및 자외선 분광학 등의 방법으로 특성을 규명하였다. 니트로벤젠 용액에서 이들 착물의 몰전도도를 측정한 결과, 비전해질 성질을 가짐을 알 았다. 또한, 모든 착물은 높은-스핀 형태였다. 분광학적 연구로부터 [MX2(L)H2O] 형의 코발트(II) 및 니켈(II) 착물은 팔면 체의 기하구조를 갖는 것으로 확인되었다. 이들 착물을 이용하여 항박테리아 및 항균 활성을 여러 종류의 병원균, 세균 및 박테리아에 대해 조사하여 생물학적 활성을 고찰하였다.

In the present paper two new thiosemicarbazones i.e., 4[N-(4'-ethylbenzalidene)amino]antipyrine thiosemicarbazone (EBAAPTS) and 4[N-(2',4'-dimethylbenzalidene)amino]antipyrine thiosemicarbazone (DMBAAPTS) have been synthesized and characterized. The complexing abilities of these thiosemicarbazones i.e. EBAAPTS and DMBAAPTS towards cobalt(II) and nickel(II) salts have been explored. The reactions of the hot ethanolic solutions of cobalt(II) and nickel(II) salts with EBAAPTS and DMBAAPTS led to the formation of the novel complexes of general composition [MX2(L)H2O] (M=Co2+ or Ni2+; X=Cl?, Br?, NO3 ?, NCS? or CH3COO?; L=EBAAPTS or DMBAAPTS). The newly synthesized complexes have been characterized by elemental analyses, molar mass, molar conductance, magnetic susceptibility, infrared and electronic spectral studies. The molar conductance measurements of the complexes in nitrobenzene correspond to their non-electrolytic nature. All the complexes are of high-spin type. On the basis of spectral studies an octahedral geometry has been assigned for Co(II) and Ni(II) complexes of the type [MX2(L)H2O]. These complexes were screened for their antibacterial and antifungal activities on different species of pathogens, fungi and bacteria and their biopotency has been discussed.

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