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ISSN 1017-2548(Print)
ISSN 2234-8530(Online)
Volume 54, Number 5
JKCSEZ 54(5)
October 20, 2010 |
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Title |
Synthesis, Characterization and Biological Activity of Some Complexes of Some New Amino Acid Derivatives N-[(Benzoyl amino)-Thioxomethyl]-Amino Acid(HL)
새로운 아미노산 유도체인 N-[(Benzoyl amino)-Thioxomethyl]-Amino Acid(HL)의 착물 합성, 특성규명 및 생물학적 활성
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Author |
Dhafir M H Al Mudhaffar*, Dawood S Al Edani, Suma M Dawood
Dhafir M H Al Mudhaffar*, Dawood S Al Edani, Suma M Dawood |
Keywords |
리간드, 아미노산, Benzoylisothiocyanate, 전이금속, 항균 활성
, Ligands, Amino acid, Benzoylisothiocyanate, Transition metals, Antibacterial activity
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Abstract |
A new series of ligands N-[(benzoylamino)-thioxomethyl]-amino acid (HL) were synthesized by reaction of benzoylisothiocyanate with various amino acids namely aspartic acid [BATA] (1), glutamic acid [BATG] (2), methionine [BATM] (3), leucine [BATL] (4), and tryptophan [BATT] (5). The ligands were characterized by elemental analysis, IR and NMR spectra. Some transition metal complexes (ML2) for these ligands (6-8) were prepared; [M=Cu(II), Co(II), or Ni(II)], and characterized by elemental analysis, IR and 1H NMR spectra. Antibacterial study showed that all the ligands have no antibacterial activity, whereas (ML2) complexes; [M = Cu(II), Co(II), or Ni(II)] have antibacterial activity towards (Gram -ive) Escherichia (NCTC5933) and (Gram +ive) Staphylococcus (NCTC6571) and have no toxicity on (BALB/C) Albino mice.
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506 - 514 |
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