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Journal of the Korean Chemical Society (JKCS)

ISSN 1017-2548(Print)
ISSN 2234-8530(Online)
Volume 53, Number 5
JKCSEZ 53(5)
October 20, 2009 

 
Title
Study on the Functionality and Application of Natural-polymer with Biocompatibility

생체적합성을 가진 천연고분자의 응용 및 기능성에 관한 연구
Author
Tae Hun Kim, Doo Eon Kim, A Young Sung*

김태훈, 김두언, 성아영*
Keywords
키토산, 생체적합성, 천연고분자 , Chitosan, Biocompatibility, Natural polymer
Abstract
천연고분자물질인 키토산은 생체적합성과 생체활성이 좋은 특성을 가지고 있기 때문에 생체의료용 재료로 중요하게 다루어지고 있다. 본 연구는 수용성 키토산을 교차결합제인 EGDMA (ethyleneglycol dimethacrylate)와 HEMA (2-hydroxyethyl methacrylate), MMA (methylmethacrylate), MA (methacrylic Acid) 그리고 개시제인 AIBN을 사용하여 공중합 하였다. 공중합한 안의료용 재료의 물리적 특성을 측정한 결과 함수율 24∼59%, 가시광선 투과율 88∼89%, 인장강도 0.1∼2.4 Kgf를 나타내었다. 또한 포도상구균, 녹농균에 대한 항균성 시험 결과 키토산을 포함하지 않은 고분자에 비해 높은 항균성을 나타내어 향후 이 공중합체가 고기능성을 가진 안의료용 재료로 사용될 수 있을 것으로 기대된다.

Chitosan, a natural polymer, has been importantly considered as biomedical materials due to its good biocompatibility and various bio-active characteristes. Water soluble chitosan was then copolymerized EGDMA(ethylene glycol dimethacrylate; used as a cross-linking agent for the free-radical copolymerization), MMA (methylmethacrylate), MA (methacrylic acid) in the presence of AIBN (azobisisobutyronitrile) as a radical initiator. The water content and visible transmissibility, ultimate strength of copolymerized ophthalmic polymer were measured to be 24∼59%, 88∼89% and 0.1∼2.4 Kgf, respectively. And also, we tested for antimicrobial activities against staphylococcus aureus, Pseudomonas aeruginosa. They showed that in case of antimicrobial activities, the values including chitosan were much higher than that of the polymers of no including chitosan, suggesting that the copolymer can be used as a novel ophthalmic material of high performance.

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547 - 552
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