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Journal of the Korean Chemical Society (JKCS)

ISSN 1017-2548(Print)
ISSN 2234-8530(Online)
Volume 52, Number 6
JKCSEZ 52(6)
December 20, 2008 

Synthesis and Antimicrobial Activity of Dimethyl (2-cyanophenylamino) (Substituted Aryl) Methyl Phosphonates

디메틸(2-시아노페닐아미노)(치환된 아릴)포스포산의 합성과 항균 활성
G Chandra Sekhar Reddy, B Siva Kumar, A Uma Ravi Sankar, M Veera Narayana Reddy, C Suresh Reddy*

G Chandra Sekhar Reddy, B Siva Kumar, A Uma Ravi Sankar, M Veera Narayana Reddy,and C Suresh Reddy*
2-아미노 벤조니트릴, 디메틸아인산염, Kabachnic-Fields 반응, α-아미노포스포산 에스테르, 항균활성도 , 2-amino Benzonitrile, Dimethylphosphite, Kabachnic-Fields Reaction, α-aminophosphonic Acid Esters, Antimicrobial Activity
새로운 계열의 α-아미노포스포산 에스테르는 같은 당량의 2-아미노 벤조니트릴, 디메틸아인산염 그리고 여 러가지 알데히드, 이 세가지 성분을 함께 반응하여 무수 톨루엔에서 환류를 통한 Kabachnic-Field반응을 거쳐 높은 수 율(74-85%)로 합성되었다. 대표 화합물의 구조는 원소, IR, 1H, 13C, 31P 그리고Mass 스펙트럼 분석으로 확인되었다. 이 분자들은 상당한 항균활성을 보였다.

A new class of α-aminophosphonic acid esters (4a-l) have been synthesized by three component one-pot reaction with equimolar quantities of 2-amino benzonitrile (1), dimethylphosphite (3) and various aldehydes (2a-l) in dry toluene at reflux conditions via Kabachnic-Fields reaction in high yields (74-85%).The structure of title compounds has been established by elemental, IR, 1H, 13C, 31P and Mass spectral analysis. They were found to possess significant antimicrobial activity.

657 - 662
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