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Journal of the Korean Chemical Society (JKCS)

ISSN 1017-2548(Print)
ISSN 2234-8530(Online)
Volume 52, Number 5
JKCSEZ 52(5)
October 20, 2008 

Unusual Formation of N-hydroxy-3,3-dimethyl-2,6-diarylpiperidin-4-one and its Thiosemicarbazide Derivative-Synthesis and Antimicrobial Activity

N-Hydroxy-3,3-dimethyl-2,6-diarylpiperidin-4-one과 그것의 Thiosemicarbazide 유도체의 특이한 합성 및 항균 활성
M. Gopalakrishnan*, P. Sureshkumar, J. Thanusu,V. Kanagarajan

M. Gopalakrishnan*, P. Sureshkumar, J. Thanusu, and V. Kanagarajan
N-Hydroxy-3,3-dimethyl-2,6-diarylpiperidin-4-one thiosemicarbazones; m-chloroperbenzoic acid,입체
화학,항균 활성도 , N-Hydroxy-3,3-dimethyl-2,6-diarylpiperidin-4-one Thiosemicarbazones, m-chloroperbenzoic Acid, Stereochemistry, Antimicrobial
다수의 새로운 N-Hydroxy-3,3-dimethyl-2,6-diarylpiperidin-4-one thiosemicarbazones들을 합성하였고 녹 는점, 원소 분석, MS, FT-IR, NMR (1H & 13C) 데이터로 구조분석 하였으며, in vitro 항균성과 항진균성의 활성을 측정하였다. 합성되어진 모든 화합물중에서, 화합물 31 은 대장균을 제외한 전체 시험되어진 gram-양성, gram-음성 박 테리아들에 대해 광범위한 항균 활성을 보여주고 있다. 화합물 31은 Aspergillus flavus, 털곰팡이, Microsporum gypsuem에 강한 항진균성을 보였다.

An array of novel N-Hydroxy-3,3-dimethyl-2,6-diarylpiperidin-4-one thiosemicarbazones 28-32 are synthesized, characterized by melting point, elemental analysis, MS, FT-IR, NMR (1H & 13C) spectroscopic data and evaluated for their in vitro antibacterial and antifungal activities. Of all the compounds synthesized, compound 31, exerted a wide range of antibacterial activities against the entire tested gram-positive and gram-negative bacterial strains except Escherichia coli. Compound 31 exerted strong antifungal activities against Aspergillus flavus, Mucor and Microsporum gypsuem.

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