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Journal of the Korean Chemical Society (JKCS)

ISSN 1017-2548(Print)
ISSN 2234-8530(Online)
Volume 52, Number 1
JKCSEZ 52(1)
February 20, 2008 

 
Title
Synthesis, Reaction and Antiviral Activity of 2,4-Diaryl-1,3-selenazoles

합성, 2,4-Diaryl-1,3-selenazoles의 항바이러스 활성도와 반응
Author
Ali Z. Al-Rubaie*, Wasfi A. Al-Masoudi, Ali Jameel Hameed, Lina Z. Yousif, Mohsen Graia

Ali Z. Al-Rubaie*, Wasfi A. Al-Masoudi, Ali Jameel Hameed, Lina Z. Yousif, Mohsen Graia
Keywords
1,3-Selenazoles, arylselenocarboxamides, α-bromoketones, X-ray, HIV-1 , 1,3-Selenazoles, arylselenocarboxamides, α-bromoketones, X-ray, HIV-1
Abstract
α-Bromoketones을 가진 1차 arylselenocarboxylic amide의 고리화는 여러가지 새로운 2,4-diaryl-1,3- selenazoles에 사용되었다. 염소, 브롬, 요오드를 사용한 2,4-diaryl-1,3-selenazoles의 할로겐화는 좋은 수율의 새로운 1,1-dihalo-2,4-diaryl-1,3-selenazoles를 준다. AIDS virus(HIV-1 and HIV-2)에 대하여 몇몇의 1,1-dihalo-2,4-diaryl- 1,3-selenazoles의 항바이러스 활성도를 검사하였다. 그것들은 HIV-1에 대한 약간의 대생물활성을 보였다. 모든 화합물은 원소분석, 1H NMR 그리고 질량 분광분석 정보로 구조분석 하였다. 2-(3,4-dimethoxyphenyl)-4-(4-bromophenyl)-1,3- selenazole의 결정구조도 보였다.

The cyclization of primary arylselenocarboxylic amides with α-bromoketones afforded a variety of new 2,4-diaryl-1,3-selenazoles. Halogenation of the 2,4-diaryl-1,3-selenazoles with chlorine, bromine and iodine gave the new 1,1-dihalo-2,4-diaryl-1,3-selenazoles in good yields. Antiviral activity of some 1,1-dihalo-2,4-diaryl-1,3-selenazoles has been tested against AIDS virus (HIV-1 and HIV-2). They showed some bioactivity against HIV-1. All compounds were characterized by their elemental analysis, 1H NMR and mass spectroscopic data. The crystal structure of 2-(3,4- dimethoxyphenyl)-4-(4-bromophenyl)-1,3-selenazole displays the molecular configuration.

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