ISSN 1017-2548(Print)
ISSN 2234-8530(Online)
Volume 49, Number 2
JKCSEZ 49(2)
April 20, 2005 

The addition of cryoprotectants as liposome stabilizes has been used to increase the stability of the redispersed liposomes in solution. We have studied the protective effect of cryoprotectants such as saccharides and amino acid derivatives on the storage stability of the liposomes when the liposome powders were redispersed in solution after freeze-drying. The liposome size before and after freeze-drying was measured to evaluate the liposome stability. Experimental conditions to maintain the stability of liposomes was optimized in procedure of redipersion with the cryoprotectants. As a result, the size of liposome was maintained in 100±5 nm with the addition of maltose or sucrose at 37 oC for 30 days, which shows the enhanced stability during the freeze-drying.