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Journal of the Korean Chemical Society (JKCS)

ISSN 1017-2548(Print)
ISSN 2234-8530(Online)
Volume 48, Number 6
JKCSEZ 48(6)
December 20, 2004 

Effects of Maltose on the Stability of Freeze-Dried Liposomes

동결 건조된 리포솜의 안정화에 있어서 말토스의 영향
Yun A Kim, Hee Dong Han, Byung Cheol Shin

김윤아, 한희동, 신병철
리포솜, 분말, 동결건조, 안정성, 칼세인, 말토스 , Liposome, Powder, Freeze-dry, Stability, Calcein, Maltose

Liposome powders were prepared by a freeze-drying method for the application to the field of drug carrier. The effect of maltose as a liposome stabilizer was studied on the stability and the drug-loading efficiency of the freeze-dried liposome powders. The particle size of liposomes before and after freeze-drying was determined to evaluate the liposome stability. The drug-loading efficiency was measured by Fluorescence spectrophotometer using calcein as a model drug. When maltose was added after the preparation of the liposomes, the liposomes was stable, compared to the case of maltose addition at the hydration procedure. By the addition of maltose, the liposome was stable for 30 days at 4~37oC, while the particle size of the liposome without maltose increased with time. The liposome showed relatively high stability when the maltose/lipids molar ratio was 3 and 6.

616 - 622
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