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Journal of the Korean Chemical Society (JKCS)

ISSN 1017-2548(Print)
ISSN 2234-8530(Online)
Volume 47, Number 6
JKCSEZ 47(6)
December 20, 2003 

 
Title
Enantioselective Reformatsky Reaction Using Cinchona Alkaloids as Chiral Ligands

Cinchona 알칼로이드를 키랄 리간드로 이용한 비대칭 Reformatsky 반응
Author
Doo Han Park*, Ho Jin Choi, Sang-Gi Lee

박두한*, 최호진, 이상기
Keywords
Cinchona 알칼로이드, 비대칭 Reformatsky 반응 , CInchona Alkaloid, Enantioselective Reformatsky Reaction
Abstract
Cinchona 알칼로이드(1-4)들을 비대칭 Reformatsky 반응에 키랄 리간드로 사용하였다. 알데히드, 리간드, Reformatsky 시약의 적가 순서에 따라 반응의 수율이 달라지며, Reformatsky 시약과 알데히드, 리간드와의 비율도 수율에 크게 영향을 주었다.

Cinchona alkaloids (1-4) were used as chiral ligands for the enantioselective Reformatsky reactions. The order of addition of the Reformatsky reagent to ligands was the important factors for the chiral induction. The ratio of Reformatsky reagent to ligand and aldehyde was also effected on the reaction yields.

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