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Journal of the Korean Chemical Society (JKCS)

ISSN 1017-2548(Print)
ISSN 2234-8530(Online)
Volume 47, Number 3
JKCSEZ 47(3)
June 20, 2003 

 
Title
Synthesis and Anti-inflammatory Activity of [2-(Benzothiazol-2-ylimino)-4-oxo-3-phenylthiazolidin-5-yl]-acetic Acid Derivatives

Synthesis and Anti-inflammatory Activity of [2-(Benzothiazol-2-ylimino)-4-oxo-3-phenylthiazolidin-5-yl]-acetic Acid Derivatives
Author
Sushilkumar S. Bahekar, Devanand B. Shinde

Sushilkumar S. Bahekar, Devanand B. Shinde
Keywords
소염제, 싸이아졸리딘아세트산 유도체, 소염작용, 항염증 , Anti-Inflammatory, Synthesis, [2-(Benzothiazol-2-ylimino)-4-oxo-3-phenylthiazolidin-5-yl]-acetic Acid, Thiazolidinylacetic Acid
Abstract
소염작용을 가진 일련의 싸이아졸리딘아세트산 유도체들을 싸이오유레아와 말레산무수물로부터 합성하고 분광학적인 방법으로 구조를 확립하였다. 또한 이 화합물들의 소염작용을 표준시약인 디클로펜악 소듐과 비교한 결과 어느정도의 효과를 가지고 있음을 검정하였다.

A synthetic method for the title compounds (2a-o) was carried out. The title compounds (2a-o)were prepared by the condensation of various thioureas and maleic anhydride. Anti-inflammatory activities in vivo were evaluated and compared with standard drug diclofenac sodium. Some compounds showed moderate activity. The structures of all the new compounds were established on the basis of 1H NMR and IR spectral data.

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