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Journal of the Korean Chemical Society (JKCS)

ISSN 1017-2548(Print)
ISSN 2234-8530(Online)
Volume 46, Number 3
JKCSEZ 46(3)
June 20, 2002

Title	Tracheal Muscle Smoothing Effect of Nobiletin Isolated from Korean Chung-pi 한국산 청피에서 분리한 Nobiletin의 기관지 평활근 이완효과
Author	Soonok Back , Jonghyun Han, Hyunja Chun , Dooseuk Han ,Sungsoo Han, Ilkwang Kim 박순옥, 한종현, 천현자, 한대석, 한성수, 김일광
Keywords
Abstract	청피의 생리활성 물질인 methoxy flavonoids를 컬럼크로마토그래피와 preparative-HPLC방법으로 분리하였으며, 흰쥐의 기관지 평활근에 미치는 이완효과를 조사하였다. Acetylcholine(ED₅₀:3×10^-6M)으로 흰쥐의 기관지 평활근을 수축시킨 후, 크로마토그래피의 분획별로 처리하였다. 수축된 기관지 평활근을 에칠아세테이트의 2차 분리 분획물로 처리한 결과, methoxy기가 6개인 flavonoid(nobiletin)의 분획물이 가장 좋은 결과를 나타내었다. 이로써 nobiletin과 그의 유사물질이 기관지 천식이나 해소의 유망한 치료제로 작용할 수 있음을 알았다. Bioactive compounds of Chung-pi, methoxy flavonoids were isolated by column chroma-tography and preparative chromatography, and investigated on the smoothing effect for the tracheal smooth mus-cle of rats. The tracheal smooth muscles of rats were treated with acetylcholine (ED₅₀: 3＊10^-6 M) and with chromatographic fractions. We found that six-methoxylated flavonoid (nobiletin) was the most active compound for the smoothing effect of which the contracted tracheal smooth muscle was screened with further separated ethyl acetate fraction. This result shows how nobiletin and its analogues could be using as a promising drug of bronchial asthma.
Page	205 - 212
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