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Journal of the Korean Chemical Society (JKCS)

ISSN 1017-2548(Print)
ISSN 2234-8530(Online)
Volume 45, Number 1
JKCSEZ 45(1)
February 20, 2001

Title	Synthesis of Mannich Bases Using Substituted Aromatic Alcohols with Secondary Amines: Relative Reactivity and Regioselectivity Depending on Substrates 치환된 방향족 알코올과 이차아민을 사용한 Mannich염기의 합성: 기질에 따른 상대적인 반응성과 위치선택성
Author	Ki-Whan Chi , Yoon Soo Ahn, Tae Ho Park , Jeong Soo Ahn, Hyun Ah Kim, Joo Yeon Park 지기환, 안윤수, 박태호, 안정수, 김현아, 박주연
Keywords
Abstract	치환된 하이드록시 방향족 화합물과 이차아민, paraformaldehyde를 비 양성자성 용매하에서 one-pot으로 반응시켜 기질에 따른 상대적인 반응성을 비교하였으며, Mannich반응이 일어난 자리도 조사하였다. 치환된 하이드록시 방향족 고리의 Mannich반응의 반응성과 위치선댁성은 기질의 친핵성도와 아민의 입체장애에 의존함을 알 수 있었다. One-pot Mannich reaction of substituted hydroxy aromatic compounds with secondary amines in an aprotic solvent has been studied. The results demonstrate that the relative reactivity and regioselectivity of the Mannich reaction depend on the steric hindrance of amines as well as the nucleophilicity of hydroxy aromatic rings.
Page	51 - 60
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