Abstract |
띠미로버섯의 에탄올 추출물 중 25-Epi, 3α-carboxyacetylquercinic acid의 두 구조, 항균활성 및 항암활성을 연구하였다. 화합물 1의 녹는점과 분자량은 각각 167∼168℃, 572였고, 몰 흡광 계수는 208 nm에서 5,040이었다. 여러 분광학적 성질로부터 이는 24S, 25S, 3α-carboxyacetylquercinic acid로 확인되었고, 곰팡이, 효모 및 세균들에 대한 항균활성과 항암활성(IC50=64.5 μM)이 있었다. 화합물 2의 녹는점, 분자량 및 몰흡광 계수는 각각 233∼235℃, 572 및 208 nm에서 5,080이었다. 이는 24S, 25R, 3α-carboxyacetylquercinic acid로 확인되었고, 화합물 1과 서로 다른 항균활성을 보였다. In order to develope bioactive substances, dried fmit body of Daedalea dickinsii collected from Taeback mountain was extracted with ethanol, The compounds 1 and 2 were purified by solvent extraction, silica gel column chromatography and recrystallization from the ethanol extracts. Melting point, molecular weight and molar extinction coefficient of the compound 1 were estimated to be 167∼168℃, 572 and 5,040 at 208 nm. The structure of this compound 1 has been elucidated to be 24S, 25S, 3α-carboxyacetylquercinic acid using spectroscopic properties. This compound showed antibiotic activities against fungi, yeasts and bacteria and it also showed anticancer activity (IC50 = 64.5μM) against Korean stomach cancer cell. Melting point, molecular weight and molar extinction coefficient of the compound 2 were estimated to be 233∼235℃, 572 and 5,080 at 208 nm. The structure of this compound was elucidated to be 24S, 25R, 3α-carboxyaeetylquercinic acid. The compound 2 showed different antibiotic activities with the compound 1. |