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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 19, Number 9
BKCSDE 19(9)
September 20, 1998 

Development of an Automated System for the Routine Preparation of Carbon-1 Labeled Radiopharmaceuticals
Seung-Jun Oh, Yearn Seong Choe, Young Sear Kim, Yong Choi, Sang Eun Kim, Kyung Han Lee, Hyun-Joon Ha, Byung-Tae Kim
An automated system was developed for the routine preparation of carbon-11 (11C) labeled radiopharmaceuticals, which consisted of three major parts including [11C]methylation of the precursor with [11C] iodomethane ([11C]CH3I), purification of the desired product and formulation of the final "C labeled radiopharmaceutical. The whole system included seven three-way slider valves, eleven solenoid valves, four pneumatic cylinders, a HPLC (High Performance Liquid Chromatography) system and a rotary evaporator. Using this system, we investigated the radiochemical synthesis of L-[methyl-11C]methionine, which is the most widely used amino acid in tumor PET (Positron Emission Tomography) studies. The overall operation took 3035 min including the production of [11C]CH3I (10.5 min) and decay-corrected radiochemical yield was 25%. The automated system we described herein can be widely utilized for the preparation of many 11C labeled radiopharinaceuticals and has been shown to be efficient, reliable and easy to operate.
952 - 956
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