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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 15, Number 7
BKCSDE 15(7)
July 20, 1994

Title	Resistance of Kanamycin- and Neomycin-Producing Streptomycetes to Aminoglycoside Antibiotics
Author	Yang Mo Goo*, Seok Rye Choi, Kyung Ja Kim
Keywords
Abstract	Streptmyces fradiae NRRL B1195 and Streptomnyces kanamyceticus IFO 13414 are highly resistant to the antibiotics they produce. The ribosomes of these organisms are found to be susceptible to the antibiotics, but the cell free extract of S fradiae is found to contain a phosphotransferase and an acetyltransferase which inactivate kanamycin and neomycin, and that of S. kanamyceticus an acetyltransferse which inactivates kanamycin and neomycin. The resistance of these organisms against streptomycin is found to be due to the resistant ribosomes; actually streptomycin activates their ribosomal systems for the synthesis of polyphenylalanine.
Page	568 - 571
Full Text	PDF

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