Current time in Korea 16:02 Jul 17 (Wed) Year 2019 KCS KCS Publications
KCS Publications
My Journal Log In Register
HOME > Search > Browsing(BKCS) > Archives

Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 15, Number 6
BKCSDE 15(6)
June 20, 1994 

 
Title
Semiempirical Molecular Orbital Calculations of the Substituent Effects on Acylations of 3-Cephem Analogues
Author
Moon-Ho Chang, Hun-Yeong Koh*, Jung-Chull Lee, Yoon Sup Lee
Keywords
Abstract
Semiempirical MO calculations are applied to estimate the substituent effects on acylations of the nonfused N-vinyl-2-amino β-lactams having frameworks analogous to 3-cephems. The stabilization energy for the reaction intermediate of the nucleophilic attack by the hydroxide ion is selected as the reactivity index and calculated by AM1 and PM3 methods for the model β-lactams with substituents at the C1 and N-vinyl terminal positions. The reactivities are larger for -SH connected to the C1 and strong Tr-acceptors at the N-vinyl terminal implying the large reactivity for known active cephalosporins. Quantum chemical calculation of stabilization energy could be useful in correlating antibiotic activities of many compounds obtained as derivatives of a lead compound.
Page
453 - 455
Full Text
PDF