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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 14, Number 2
BKCSDE 14(2)
February 20, 1993 

 
Title
Synthesis of 4-Aza-cholestane Derivatives Containing Nitrosoureido Function as Antitumor Activity
Author
Jack C. Kim*, Jin Il Park, Tae-Ho Hur
Keywords
Abstract
A series of 4-(2-chloroethyl)nitrosocarbamoyl-and 4-methyl nitrosocarbamoyl analogs of 4-Aza-5α -cholestane (5a and 5b), 4-Aza-5-cholestene (6a and 6b) were synthesized and evaluated for their inhibitory activity against the Sarcoma 180 cell. The steroidal nitrosoureas, 5a, 5b, 6a and 6b displayed modest activity in vitro.
Page
176 - 178
Full Text
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