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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 14, Number 1
BKCSDE 14(1)
January 20, 1993 

 
Title
Synthesis of Cephalosporins Having a Heterocyclic Group at the C-3 Position
Author
Myung Hee Jung*, Kui-Woong Cho, Wan Joo Kim, Joon-Seob Shin, Choong Sil Park
Keywords
Abstract
3-(3-Bromotetrahydrofuran-2-yl)-3-cephem 7 was obtained from 3-(2-hydroxyethyl)vinyl-3-cephem 6 by the cyclization reaction using N-bromosuccinimide. Compound 5 was prepared by Wittig reaction, namely a coupling of cephem-derived triphenylphosphonium salt 3 with aldehyde component 4 in the presence of base.
Page
32 - 34
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