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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 11, Number 5
BKCSDE 11(5)
May 20, 1990 

Structure and Activity of Quinolone Antibacterial Agents. 1,7-Substituted 1-Ethyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic Acids
Youn Ho Shin, Eung K. Ryu, Young Kee Kang*
To find out a correlation between antibacterial activity and physical properties of 7-substituted 1-ethyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carb oxylic acid, dipole moments, charge distributions, and hydrophobicities were calculated. The atomic charges and the dipole moments to not give any correlations with inhibition of DNA gyrase, but the calculated hydration free energies show some correlations.
376 - 379
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