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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 11, Number 3
BKCSDE 11(3)
March 20, 1990

Title	Synthesis of Novel Acyclonucleosides ; Reactions of Diazinone Heterocycles with 4-Bromoacetoacetic acid and Methyl 4-bromoacetoacetate
Author	Sam Yong Choi, Sung Chul Shin, Young Jin Yoon*
Keywords
Abstract	Some substituted pyridazin-6-ones(1-4) and two uracils(10,12) have been converted to the corresponding N1-(2-oxopropyl)pyridazine-6-ones(6-9), 1,3-bis(2-oxopropyl)-5-fluorouracil(11) and 2-(2-oxopropylthio)uracil(13) respectively by reaction with 4-bromoacetoacetic acid. Also, 4,5-dichloro-1-(3-carbomethoxy-2-oxopropyl)pyrida zin-6-one(15) and 4,5-dichloro-3-nitro-1-(3-carbomethoxy-2-oxopropyl )pyridazin-6-one(16) was synthesized from the corresponding pyridazin-6-ones(1,2) and methyl 4-bromoacetoacetate.
Page	228 - 231
Full Text	PDF

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