Current time in Korea 06:58 May 27 (Mon) Year 2019 KCS KCS Publications
KCS Publications
My Journal Log In Register
HOME > Search > Browsing(BKCS) > Archives

Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 11, Number 1
BKCSDE 11(1)
January 20, 1990 

 
Title
Synthesis of 4, 5, 6, 7-Tetraphenyl-8-(substituted)-3 (2H)-phthalazinone Derivatives Likely to Posses Antihypertensive Activity
Author
F. A. Yassin, B. E. Bayoumy*, A. F. El-Farargy
Keywords
Abstract
The interaction of tetraphenylphthalic anhydride with o-chlorotoluene under Friedel-Craft condition gives 2-(4-chloro-3-methyl)benzoyl-3,4,5,6-tetraphenyl benzoic acid(1), which on reaction with hydrazine derivatives gave phthalazinones (2a-d). The behaviour of (2a) towards carbon electrophiles and carbon nucleophiles has been investigated. The chlorophthalazinones (4a) also has been synthesized from the action of PCl5/POCl3 on (2a). The behaviour of (4a) towards nitrogen, and oxygen nucleophiles also have been described.
Page
7 - 10
Full Text
PDF