KCS Publications

HOME > Search > Browsing(BKCS) > Archives

Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 10, Number 4
BKCSDE 10(4)
April 20, 1989

Title	Peptide Synthesis with Polymer Bound Active Ester. I. Rapid Synthesis of Peptides Using Polymer Bound 1-Phenyl-3-methyl-4-oximinopyrazole
Author	Ki-Wha Lee, Yoon-Sik Lee*
Keywords
Abstract	Polymer bound 1-phenyl-3-methyl-4-oximinopyrazoles were prepared through a series of chemical modifications of Merrifield's resin (chloromethylpolystyrene-1% DVB-copolymer). Several polymer active esters of N-blocked amino acids were prepared from the polymer bound 1-phenyl-3-methyl-4-oximinopyrazoles. Polymer bound active esters were found to be highly reactive in N-acylation reaction. The resins were tested for the preparation of several dipeptides. The peptides were obtained in high yields within 10 minutes and the progress of the reactions could be easily followed up by the color change of the resin. The resulting peptides were characterized by NMR and other physical methods.
Page	331 - 335
Full Text	PDF

How to access to the WOL for The Bulletin of the Korean Chemical Society ?

The Bulletin of the Korean Chemical Society will be co-published with Wiley-VCH from 2015 towards. The online version of the Journal will thus be available on Wiley Online Library, Wiley(-VCH)'s global online platform.

KCS members can get a free online access to the Bulletin of the Korean Chemical Society in WOL.

Free Access to WOL