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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 9, Number 6
BKCSDE 9(6)
June 20, 1988

Title	A Charge-Transfer Effect in Solid Phase Peptide Synthesis: Unsusally High Reactivity in Peptide Bond Formation between p-Nitrobenzophenone Oxime Resin Ester and Amino Acid 4-(Methylthio)phenyl Ester
Author	Dong-Hyun Park, Jae-Kyu Jung, Yoon-Sik Lee*
Keywords
Abstract	Unusually high reactivity was found in peptide bond formation between p-nitrobenzophenone oxime resin (Ⅰ) ester and amino acid 4-(methylthio)phentyl (MTP) esters. A charge-transfer complex between the two phenyl rings of the oxime resin (Ⅰ) and the incoming amino acid MTP esters was considered to be responsible to accelerate the aminolysis reaction of the peptide oxime resin ester. Several di-, tri-, and pentapeptide fragments for preparing enkephalin and glutathione oligomers were successfully prepared in short times.
Page	394 - 398
Full Text	PDF

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