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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 9, Number 5
BKCSDE 9(5)
May 20, 1988

Title	Interaction Metal Ions with NADH Model Compounds. Cupric Ion Oxidation of Dihydronicotinamides
Author	Joon Woo Park*, Sung Hoe Yun, Kwanghee Koh Park
Keywords
Abstract	Kinetic studies on cupric ion (Cu2+) oxidation of 1-benzyl- and 1-aryl-1,4-dihydronicotinamides (XNAH) in aqueous solution were performed. In the presence of dioxygen (O2), the reaction followed first order kinetics with respect to both XNAH and Cu2+. The oxidation reaction was found to be independent and parallel to the acid-catalyzed hydration reaction of XNAH. The catalytic role of Cu2+ for the oxidation of XNAH in the presence of O2 was attributed to Cu2+/Cu+ redox cycle by the reactions with XNAH and O2. The second order rate constants of the Cu2+ oxidation reaction kCu, and acid-catalyzed hydration reaction kH were strongly dependent on the nature of the substituents in 1-aryl moiety. The slopes of log kCu vs log KH and log kCu vs σp of the substituents plots were 1.64 and -2.2, respectively. This revealed the greater sensitivity of the oxidation reaction rate to the electron density on the ring nitrogen than the hydration reaction rate. A concerted two-electron transfer route involving XNAH-Cu2+ complex was proposed for mechanism of the oxidation reaction.
Page	298 - 303
Full Text	PDF

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