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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 9, Number 5
BKCSDE 9(5)
May 20, 1988 

 
Title
Synthesis of Acyclic Nucleosides of 2-Thio-Pyrimidines and -Purines Using a New Coupling Agent of Lithium Bromide
Author
Joong Young Kim, Yong Hae Kim*
Keywords
Abstract
Acyclic nucleosides, 1-[[1,3-bis(benzyloxy)-2-propoxy]methyl]-2-thiopy rimidine, 9-[[1,3-bis(benzyloxy)-2-propoxy]methyl]-6-amino -2-thiopurine, 1-(2-acetoxyethoxymethyl)-2-thiopyrimidine, and 9-[[1,3-bis(benzyloxy)-2-propoxy]methyl]-6-amino -2-thiopurine have been synthesized by coupling pyrimidine and purine bases with acyclic acetates using a new coupling reagent of lithium bromide in the presence of trifluoro acetic acid in acetonitrile.
Page
295 - 298
Full Text
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