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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 9, Number 5
BKCSDE 9(5)
May 20, 1988 

 
Title
Mechanistic Studies on the Photochemical Degradation of Nifedipine
Author
Sang Chul Shim*, Ae Nim Pae, Yong Jai Lee
Keywords
Abstract
Irradiaton of nifedipine in methylene chloride at 366 nm yielded 2,6-dimethyl-3,5-dicarbomethoxy-4-(2'-nitrosophen yl)-pyridine with the quantum yield 0.37, while irradiation at 254 nm initially gave nitroso compound which in turn is photooxidized to 2,6-dimethyl-3,5-dicarbomethoxy-4-(2'-nitrophenyl) -pyridine with the quantum efficiency of 0.014 on further irradiation in the presence of oxygen. The intramolecular hydrogen abstraction of nifedipine proceeded from the triplet excited sitate.
Page
271 - 274
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