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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 8, Number 4
BKCSDE 8(4)
April 20, 1987 

 
Title
An Effective Acylation of Cephalosporins Using 1-Methanesulfonyloxy-6-trifluoromethylbenzotriazole
Author
Cheol Hae Lee*, Chi Jang Moon, Kyeong Sook Kim, Jae Hak Kim, Dae Whang Kim
Keywords
Abstract
A new coupling agent, 1-methanesulfonyloxy-6-trifluoromethyl-benzotriazo le (3), was prepared by the reaction of 1-hydroxy-6-trifluoromethylbenzotriazole (1) and methanesulfonyl chloride. 3 was reacted with 2-(2-amino-4-thiazolyl)-2-synalkoxyiminoacetic acid (4) to give a mixture of active intermediates (5 and 6), which was treated with 7-aminocephalosporanic acid derivatives (10) to afford cephalosporin derivatives (11) in short reaction time with high yields.
Page
336 - 338
Full Text
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