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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 8, Number 1
BKCSDE 8(1)
January 20, 1987

Title	Liquid Chromatographic Resolution of Racemic Drugs on Various α-Arylalkylamine Derived Chiral Stationary Phases
Author	Myung Ho Hyun*, William H. Pirkle
Keywords
Abstract	After conversion to their 3,5-dinitrobenzoyl or 3,5-dinitroanilide derivatives, the enantiomers of a number of drugs may be chromatographically separated on various α-arylalkylamine-derived chiral stationary phases (CSPs). While each CSP used in this study is useful, CSP 1 is best able to resolve the 3,5-dinitroanilide derivative of Ibuprofen while CSP 9 generally gives rather large α values for the resolution of 3,5-dinitrobenzoyl derivatives of the enantiomers of β-adrenergic blocking drugs.
Page	45 - 47
Full Text	PDF

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