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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 35, Number 12
BKCSDE 35(12)
December 20, 2014 

A New Flavonol Glycoside from the Leaves of Boscia senegalensis
Abubaker M. A. Morgan, Jang Hoon Kim, Sang Kyum Kim, Chi-Hwan Lim, Young Ho Kim*
Boscia senegalensis, Capparaceae, Flavonol glycoside, Soluble epoxide hydrolase
Detailed chemical investigation of Boscia senegalensis (Per) Lam. ex Poir. led to the isolation of one new flavonol glycoside, rhamnocitrin-3-O-β-D-(6''-O-E-feruloyl)-glucopyranoside named bosenegaloside A (1), with seven known compounds, rhamnocitrin-3-O-β-D-(6''-O-E-p-coumaroyl)-glucopyranoside (2), rhamnocitrin- 3-O-β-D-glucopyranoside (3), 3,4,5-trimethoxyphenol-β-D-glucopyrinoside (4), lasianthionoside A (5), 3,7- dimethyl-1-octene-3,6,7-triol-6-O-β-D-glucopyranoside (6), syringin (7), and austroside B (8). The chemical structures of these compounds were elucidated from spectroscopic data and by comparison of these data with previously published results. The inhibitory activity of the isolated compounds on soluble epoxide hydrolase (sEH) was assessed. Compounds 1-3 potently inhibited sEH activity with IC50 values of 12.8 ± 0.5, 18.4 ± 0.2, and 11.3 ± 0.9 μM, respectively.
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