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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 35, Number 11
BKCSDE 35(11)
November 20, 2014 

 
Title
Two Androstane Derivatives from the Cultures of Fungus Marasmiellus ramealis (Bull.) Singer
Author
Ning-Ning Yang, Qing-Yun Ma, Sheng-Zhuo Huang, Hao-Fu Dai, Zhi-Kai Guo, Zhi-Fang Yu*, You-Xing Zhao*
Keywords
Marasmiellus ramealis (Bull.) Singer, Fermentation, Androstane derivative, AChE inhibitory activity
Abstract
A new androstane derivative, 4β-methyl-15-oxa-14β-androstane-7-ene-4α-carboxylic acid (1) and a known one 4β-methyl-15-oxa-14β-androstane-7-ene-4α-hydroxyl (2) were isolated from the EtOAc extract of the cultures of the fungus Marasmiellus ramealis (Bull.) Singer. Their structures were elucidated on the basis of 1D and 2D NMR as well as MS spectroscopic data analysis. The inhibitory activity of two isolates against acetylcholinesterase (AChE) revealed that compound 1 exhibited definitely inhibitory activity.
Page
3224 - 3226
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