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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 35, Number 11
BKCSDE 35(11)
November 20, 2014 

Ultra-sensitive Determination of Salinomycin in Serum Using ICP-MS with Nanoparticles
H. K. Cho, H. B. Lim*
Bioanalysis, Antibiotic detection, Particle tagging, ICP-MS, Nanoparticles
An ultra-sensitive detection method for small molecules such as antibiotics was developed using ICP-MS with magnetic and TiO2 nanoparticles. Since most of the antibiotics are too small to employ a sandwich-type extraction through an immunoreaction, a non-specific platform was employed, in which the target was extracted by magnetic separation, followed by tagging with TiO2 nanoparticles of 11.2 nm for ICP-MS measurement. The detection limit for salinomycin obtained from spiked serum samples was 0.4 ag mL−1 (± 10.3%), which was about 1.5 × 106 times lower than that of LC-MS/MS and about 1.2 × 1011 times better than that of ELISA. Such an excellent sensitivity enabled us to study the toxicity of antibiotics exposed to human beings by determining them in serum.
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