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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 35, Number 8
BKCSDE 35(8)
August 20, 2014 

 
Title
Synthesis and In vivo Evaluation of 5-Methoxy-2-(phenylethynyl)quinoline (MPEQ) and [11C]MPEQ Targeting Metabotropic Glutamate Receptor 5 (mGluR5)
Author
Ji Young Kim, Myung-Hee Son, Kihang Choi, Du-Jong Baek, Min Kyung Ko, Eun Jeong Lim, Ae Nim Pae, Gyochang Keum, Jae Kyun Lee, Yong Seo Cho, Hyunah Choo, Youn Woo Lee, Byung Seok Moon, Byung Cheol Lee, Ho-Young Lee*, Sun-Joon Min*
Keywords
MPEQ, Metabotropic glutamate receptor 5 (mGluR5), in vivo, PET imaging, Neuropathic pain
Abstract
The synthesis and in vivo evaluation of 5-methoxy-2-(phenylethynyl)quinoline (MPEQ) 3 as a potential mGluR5 selective radioligand is described. We have identified MPEQ 3 exhibiting the analgesic effect in the neuropathic pain animal model. The effect of mGluR5 on neuronal activity in rat brain was evaluated through FDG/PET imaging in the presence of MPEQ 3. In addition, the PET study of [11C]MPEQ 3 proved that accumulation of [11C]MPEQ 3 in rat brain was correlated to the localization of the mGluR5.
Page
2304 - 2310
Full Text
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