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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 35, Number 7
BKCSDE 35(7)
July 20, 2014 

A Facile and Efficient Synthesis of Dronedarone Hydrochloride
Feng Li, Chunhua Jin*, Jianwei Zou, Jun Wu
Dronedarone, Tandem-type synthesis, Cyclization, CO2 fixation
A facile and efficient synthesis of dronedarone hydrochloride starting from commercially available 4- nitrophenol is described. This approach features a tandem-type synthesis of 3-carbonylated benzofuran involving cyclization of 2-ethynylphenol followed by CO2 fixation at the 3-position of the benzofuran ring mediated by potassium carbonate without the addition of any transition metal catalyst.
1970 - 1972
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