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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 35, Number 6
BKCSDE 35(6)
June 20, 2014 

Synthesis of Gold Nanoparticles by Electro-reduction Method and Their Application as an Electro-hyperthermia System
Young Il Yoon, Kwang-Soo Kim, Yong-Soo Kwon, Hee-Sang Cho, Hak Jong Lee, Chang-Jin Yoon*, Tae-Jong Yoon*
Gold nanoparticles, Radiofrequency ablation, Electro-hyperthermia, Heat shock, Biocompatible nanomaterials
We report the successful preparation of gold nanoparticles (Au NPs) using a novel electroreduction process, which is simple, fast, and environmentally friendly (toxic chemicals such as strong reducing agents are not required). Our process allows for the mass production of Au NPs and adequate particle size control. The Au NPs prepared show high biocompatibility and are non-toxic to healthy human cells. By applying radiofrequency (RF) ablation, we monitored the electro-hyperthermia effect of the Au NPs at different RFs. The Au NPs exhibit a fast increase in temperature to 55 °C within 5 min during the application of an RF of 13 MHz. This temperature rise is sufficient to promote apoptosis through thermal stress. Our work suggests that the selective Au NP-mediated electro-hyperthermia therapy for tumor cells under an RF of 13 MHz has great potential as a clinical treatment for specific tumor ablation.
1806 - 1808
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