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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 35, Number 6
BKCSDE 35(6)
June 20, 2014

Title	A Facial Protocol for the Synthesis of Benzofuran Derivatives by the Reaction of o-Hydroxy Aryl Ketone, Amine and Chloroacetyl Chloride
Author	Shuai Xia, Xiu-Hua Wang, Ji-Qiang Liu, Chang Liu, Jian-Bin Chen, Hua Zuo, Yong-Sheng Xie, Wen-Liang Dong, Dong-Soo Shin
Keywords	Benzofuran, o-Hydroxy aryl ketone, Amine, Synthesis, Intramolecular condensation
Abstract	A facile and effective method has been developed for the synthesis of a novel series of benzofuran derivatives via N-acylation, O-alkylation and intramolecular condensation reactions, starting from readily available substituted o-hydroxy aryl ketone, and chloroacetyl arylamides. This metal-free transition process is characterized by mild reaction conditions, atom economy, short reaction time and a high yield with a decreased amount of by-products.
Page	1743 - 1748
Full Text	PDF

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