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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 35, Number 6
BKCSDE 35(6)
June 20, 2014

Title	Three Component Solvent-free Synthesis of Chroman-2,4-dione-based Heterocyclic Ketene Aminal (HKA) Derivatives by “GAP” Chemistry
Author	Fu-Chao Yu, Xiao-Pan Hao, Xiu-Yang Jiang, Sheng-Jiao Yan, Jun Lin
Keywords	GAP chemistry, Heterocyclic ketene aminals (HKAs), 4-Hydroxycoumarin, Chroman-2,4-dione
Abstract	A concise and efficient one-pot synthesis of chroman-2,4-dione-based HKA derivatives by three component reaction of HKAs, triethoxymethane and 4-hydroxycoumarin derivatives under solvent-free and catalyst-free conditions is described. This protocol has many advantages, in that the GAP (Group-Assistant-Purification) chemistry process is involved in this method. As a result, the experimenter can avoid cumbersome process steps such as traditional chromatography and recrystallization purifications. The desired products can be easily obtained by washing the crude products with 95% EtOH.
Page	1625 - 1632
Full Text	PDF / Supporting Information

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