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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 34, Number 8
BKCSDE 34(8)
August 20, 2013 

Facile Synthetic Routes to Prepare α-Muricholic Acid, Hyocholic Acid, and Their Taurine Conjugates
Dong Wook Kang*, Hans F. Luecke*
Bile acids, α-Muricholic acid, Hyocholic acid, Taurine conjugates, Metabolites
α-Muricholic acid was synthesized through 9 steps from chenodeoxycholic acid with 26% overall yield. Hyocholic acid was synthesized through 8 steps from the same starting material with 63% overall yield. Taurine conjugates of α-muricholic acid and hyocholic acid were also prepared via their pentafluorophenyl ester.
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