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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 34, Number 7
BKCSDE 34(7)
July 20, 2013 
 
Title
 Synthesis of Water Soluble Analogs of Arylsulfonylimidazolidinone (JSH-2282)
Author
 Seong-Cheol Bang, Ki-Cheul Lee, Vinay K. Sharma, Niti Sharma, Hyun-Sun Yang, Sang-Hun Jung*
Keywords
 Arylsulfonylimidazolidinone, Solubility, Cytotoxicity, Anti-cancer
Abstract
 To improve the water solubility of arylsulfonylimidazolidinone (JSH-2282), a potent anti-cancer agent, two urea derivatives, sodium (S)-2-(3-(4-(5-((S)-2-oxo-4-phenylimidazolidin-1-ylsulfonyl)indoline-1-carbonyl)- phenyl)ureido)succinate (2a) and sodium (S)-2-(3-(4-(5-((S)-2-oxo-4-phenylimidazolidin-1-ylsulfonyl)indoline- 1-carbonyl)phenyl)ureido)pentanedioate (2b), were synthesized and studied for solubility and anti-cancer activity.
Page
 2011 - 2015
Full Text
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