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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 34, Number 6
BKCSDE 34(6)
June 20, 2013

Title	Optimization of the Reaction Conditions for Synthesis of 3-(Aryloxy)quinoline Derivatives via Friedländer’s Cyclization Reaction
Author	Mohammad Ashrafuddin Khan, Mohammed I. El-Gamal, Chang-Hyun Oh*
Keywords	Cyclization reaction, 2-Amino-4,5-dimethoxybenzaldehyde, Friedländer’s reaction, Quinoline
Abstract	6,7-Dimethoxy-2-methyl-3-(4-nitrophenoxy)quinoline was synthesized by Friedländer’s cyclization reaction. Different bases and solvents were tested in order to optimize the reaction conditions. The highest yields were obtained using piperidine in refluxing ethanol. Further reactions were carried out in order to prepare different diarylamide and diarylurea derivatives in moderate to high yields in order to examine their anticancer activities.
Page	1848 - 1852
Full Text	PDF

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