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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 33, Number 12
BKCSDE 33(12)
December 20, 2012 

In-vitro and in-vivo Behaviors of Poly(glycolide-caprolactone) Copolymer for Bioabsorbable Suture Materials
Yeon-Chun Yoo, Hak-Yong Kim*, Fan-Long Jin, Soo-Jin Park*
Poly(glycolide-caprolactone), Absorbable suture, Monofilament, Biocompatibility
A novel bioabsorbable suture material, poly(glycolide-caprolactone) (PGLCL) monofilament, was prepared by spinning of the PGLCL copolymer. The physical properties, strength retention, biocompatibility, and organism resolvability of the PGLCL monofilament were investigated. The results showed that the knot pull strength of the monofilament was higher than that stated in European Pharmacopoeia. The in vivo retention strength following implantation was 64%, 23%, 7%, and 0% after one, two, three, and four weeks, respectively. Mortality, clinical signs, validation, and sterility tests indicated that all items had passed. Organism resolvability tests showed that the PGLCL monofilament, as a suture, was absorbed within 91 days.
4137 - 4140
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