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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 33, Number 12
BKCSDE 33(12)
December 20, 2012 

 
Title
Rapid Determination of Volatile Organic Compounds in Human Whole Blood Using Static Headspace Sampling with Gas Chromatography and Mass Spectrometry
Author
Ji-Young Lee, Seungki Kim, Jong-Tae Lee, Jong-Ho Choi, Jeongae Lee, Heesoo Pyo*
Keywords
VOCs, Whole blood, Headspace, HS-GC-MS
Abstract
Headspace (HS) and headspace solid-phase microextraction (HS-SPME) were studied for extracting volatile organic compounds (VOCs) from whole blood, with chemical and instrumental variables being optimized for maximum sensitivity: incubation at 60 °C, equilibration for 30 min, pH 11, and 2 mL injection volume. Both techniques provided accurate analyses, with detection limits of 0.05-0.1 ng mL−1 and 0.05-0.5 ng mL−1. HS showed better sensitivity, reproducibility, and analysis times than HS-SPME. Overall levels of chloroform in whole blood were found to be 0.05-5.84 ng mL−1; detected levels of benzene were 0.05-2.20 ng mL−1.
Page
3963 - 3970
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