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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 33, Number 11
BKCSDE 33(11)
November 20, 2012

Title	New Safrole Oxide Derivatives: Synthesis and in vitro Antiproliferative Activities on A549 Human Lung Cancer Cells
Author	Li-Ying Wang, Xiu-Hua Wang, Jia-Lian Tan, Shuai Xia, Heng-Zhi Sun, Jin-Wen Shi, Ming-Dong Jiang, Liang Fang, Hua Zuo, Gautam Dupati, Kiwan Jang, Dong-Soo Shin
Keywords	Safrole derivatives, A549 cells, MTT assay, Growth inhibition
Abstract	A number of novel small molecules, safrole oxide derivatives 4a-c, 6a-c, 9a-h, were synthesized by the reaction of safrole oxide with anilines 3 and 5, or its alkyl allyl ether derivative 7 with alkyl bromide 8 in moderate yields. The antiproliferative effects of all the target molecules on A549 cell growth were investigated and it was found that the 14 novel compounds could suppress A549 lung cancer cell growth. Among them, compound 6b was the most effective compound in inhibiting the proliferation of A549 cells.
Page	3571 - 3575
Full Text	PDF / Supporting Information

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