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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 33, Number 9
BKCSDE 33(9)
September 20, 2012

Title	A Straightforward Synthesis of K-7174, a GATA-Specific Inhibitor
Author	Mahesh S. Majik, Jin Ha Yu, Lak Shin Jeong*
Keywords	K-7174, Wittig reaction, GATA-inhibitor, Iodine-catalyzed isomerization
Abstract	K-7174, a GATA-specific inhibitor, is a putative anti-inflammatory agent that attenuates effects of inflammatory cytokines in certain cell types. An expeditious four-step synthesis of K-7174 is described in this paper. The route employs Wittig olefination and bis-alkylation of homopiperazine as the key reactions. The iodinecatalyzed isomerization of the Z-isomer results in complete conversion to the E-isomer is the highlight of our synthetic endeavors.
Page	2903 - 2906
Full Text	PDF

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