Current time in Korea 06:47 Dec 08 (Sun) Year 2019 KCS KCS Publications
KCS Publications
My Journal Log In Register
HOME > Search > Browsing(BKCS) > Archives

Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 33, Number 6
BKCSDE 33(6)
June 20, 2012 

Design and Synthesis of Oxime Ethers of β-Oxo-γ-phenylbutanoic Acids as PPAR α and -γ Dual Agonists
Hee Oon Han, Jong Sung Koh, Seung Hae Kim, Ok Ku Park, Kyoung-Hee Kim, Sang Kweon Jeon, Gwong-Cheung Hur, Hyeon Joo Yim, Geun Tae Kim*
PPAR α and γ dual agonist, Diabetes, Oxime ethers, β-Oxo-γ-phenylbutanoic acid
Oxime ethers of β-oxo-γ-phenylbutanoic acids were prepared to develop more effective PPAR α and γ dual agonists. Among them, compound 11k exhibited potent in vitro activities with EC50 of 2.5 nM and 3.3 nM in PPAR α and γ, respectively. It showed better glucose lowering effects than rosiglitazone 1 and improved the lipid profile like plasma triglyceride in db/db mice model.
1979 - 1982
Full Text
PDF / Supporting Information