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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 33, Number 5
BKCSDE 33(5)
May 20, 2012

Title	Design, Synthesis and In Vitro Cytotoxic Activity Evaluation of New Mannich Bases
Author	Bui Trung Hieu, Le Thi Thuy, Vu Thu Thuy, Hoang Xuan Tien, Luu Van Chinh, Vu Dinh Hoang, Tran Khac Vu*
Keywords	Anticancer, Cytotoxicity, Chalcone, Mannich, Paraformaldehyde
Abstract	A series of Novel Mannich bases has been synthesized and evaluated in vitro cytotoxic activity against the human hepatocellular carcinoma (HepG2), human lung carcinoma (SK-LU-1), and human breast cancer (MCF-7). Compound 9f was found to be most potent against three cell lines with IC50 values of 1.57, 1.16 and 1.21 μg/mL, respectively. In addition, compounds 9g, 10f exhibited very significant activity against MCF-7 cell line with IC50 values of 2.0 μg/mL.
Page	1586 - 1592
Full Text	PDF

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